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OPTIMUM
  • Home
  • For Participants
  • For Clinicians
  • Locations
    • Los Angeles
    • New York
    • Pittsburgh
    • Saint Louis
    • Toronto
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OPTIMUM is a research
study designed to test which medications work best and are safest for adults age sixty and older with difficult-to-treat depression.



Who is eligible for OPTIMUM


Inclusion
-Age 60 or older
-Treatment Resistant 
 -Depression, defined
  by:
  •Major depression
  •PHQ-9 =  6 or
   greater
  •Two or more trials
   of antidepressant
   medications

Exclusion
-Dementia
-Unstable medical  
  illness
-Unable to take any 
 of the OPTIMUM
 medications


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ow OPTIMUM Works

How do I refer my patients?
Contact us to refer your patients. We’ll screen your patients and let you know when your patient is eligible.

What can I expect?
We will ask you to prescribe a step 1 medication at a specific dose. You prescribe it. If your patient does not respond to, tolerate or qualify for
Step 1 medication, they move to Step 2: add lithium or switch to nortriptyline.

How is the medication managed?
We’ll call your patient every two weeks for brief counseling and ask about symptoms and side effects. We then recommend that you raise or lower the dose, stay the course, or stop the medication. This partnership provides measurement-based collaborative care to your patients.

What if the patient has a side effect or other problem?
Report it to us; we will follow-up. The study psychiatrists can provide clinical recommendations to you and your patient based on safety labs and drug monitoring.

How will we be compensated for our time?
Participants will be compensated $50 for the initial screening visit and $25 for each assessment visit after that. Clinicians will also receive compensation for their time.




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OPTIMUM study design

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Study medication
prescribing information

Aripiprazole
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Bupropion
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Lithium
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nortriptyline
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Insurance Coverage for medication and clinical care
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Los Angeles
(310) 206-5240
LateLifeWellness@
mednet.ucla.edu
New York
(646)774-8648

cgarcia@nyspi.columbia.edu
Pittsburgh
(412) 586-9851

optimumstudy@upmc.edu

Saint Louis
(314) 273-7034
optimum@wustl.edu

Toronto
(416) 583-1227
optimum@camh.ca
OPTIMUM is a multi-site research study. © Copyright 2017 All rights reserved.
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  • Home
  • For Participants
  • For Clinicians
  • Locations
    • Los Angeles
    • New York
    • Pittsburgh
    • Saint Louis
    • Toronto